CommPath, an open source R package and a webserver, to infer and visualize the LR associations and signaling pathway-driven cell-cell communications from scRNA-seq data.

CommPath has two key features:

  • Manually curates a comprehensive signaling molecule interaction database of LR interactions, as well as their currently accessible pathway annotations, including KEGG pathways, WikiPathways, reactome pathways, and GO terms;
  • Prioritizes both LR pairs among cell types and cell type specific signaling pathways mediating cell-cell communications.